Chitosan is a dietary fibre derived from chitin found in the shells of shellfish. The alkaline deacetylation of chitin (aminopolysaccharide, or a combination of a sugar and a protein) leads to the formation of chitosan. Chitosan is a (positively-charged) large fibre molecule that has the ability to attract and bind to fatty acids (which carry a negative charge). After forming "films" with the fats in the digestive system, it is not specifically hydrolyzed and, therefore, may bind the fats and pass them through the body undigested. Specifically, it is the positively charged tertiary amino group (-NH3+) of chitosan that attracts the anionic carboxyl groups of fatty acids and bile acids. Chitosan also binds with cholesterol (and other neutral lipids) with hydrophobic bonds thereby reducing cholesterol levels in the blood.

ARS Medicina (Helsinki) Report of 1994 is one of the most popular researches done on Chitosan. The study was performed at the ARS Medicina in Helsinki, Finland from mid-August to October of 1994. Jan Abelin, M.D. and Allan Lassus, M.D. conducted the study.

The average weight loss for the chitosan group was a full 15 pounds in a 4-week period, whereas the placebo group only had a weight loss average of 5 pounds. The weight reduction was also associated with a significant decrease in blood pressure. The average diastolic blood pressure reading fell 20 millimeters of mercury with an additional 9 millimeters of mercury pressure drop in the systolic.

It is a known fact that being overweight is a contributor to high blood pressure, which in turn may lead to stroke. Here we have a single product that reduces body weight and lowers the blood pressure with no side effects whatsoever. The researchers concluded that in this trial, chitosan appeared to be nontoxic, well-tolerated, effective natural product in helping people achieve weight reduction and normal blood pressure.

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